Icariin on relaxation effect of corpus cavernosum smooth muscle |
| |
Authors: | Zhongcheng Xin Kim Euikyung Zhenji Tian Guiting Lin Yinglu Guo |
| |
Institution: | (1) Department of Urology, The First Hospital, Peking University, 100034 Beijing, China;(2) Department of Life Science, Pohang University of Science and Technology, Pohang, Korea |
| |
Abstract: | NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is
regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine
5′ monophosphate (GMP) by phosphodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to
have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4×10−4 mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum believed to have the inhibiting effect
on PDE5 and activation of NO-cGMP pathway to enhancing penile erection. |
| |
Keywords: | Icariin corpus cavernosm cGMP erection |
本文献已被 SpringerLink 等数据库收录! |
| 点击此处可从《中国科学通报(英文版)》浏览原始摘要信息 |
| 点击此处可从《中国科学通报(英文版)》下载免费的PDF全文 |