| 氟比洛芬酯超前镇痛在全麻下扁桃体摘除术的应用 |
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| 引用本文： | 龙云辉,唐新龙,吴敏仙,王菊,顾惠丽,伍贤德,刘霞.氟比洛芬酯超前镇痛在全麻下扁桃体摘除术的应用[J].科技资讯,2008(2). |
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| 作者姓名： | 龙云辉 唐新龙 吴敏仙 王菊 顾惠丽 伍贤德 刘霞 |
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| 作者单位： | 上海市宝山区中心医院麻醉科 |
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| 摘 要： | 目的探讨氟比洛芬酯超前镇痛在全麻下扁桃体摘除术的应用。方法ASAI-Ⅱ级,择期行全麻下扁桃体摘除术患者60例,随机分为两组,每组30例。Ⅰ组(观察组)患者麻醉诱导前静脉缓慢注射氟比洛芬酯注射液100mg;Ⅱ组(对照组)不注射氟比洛芬翻注射液.分别记录两组患者术后2、6、12、24h的疼痛视觉模拟评分(VAS);咽喉疼痛发生率以及麻醉镇痛相关的不良反应;术毕时,术后12h和术后24h各取外周血2mL,检测PGE_2(前列腺素E_2)浓度.结果观察组术后2、6,12h VAS明显低于对照组(P<0.01),两组术后24hVAS比较差异无显著意义(P>0.05),两组与麻醉镇痛有关的不良反应之间比较无显著意义(P>0.05),但咽痛发生率观察组低于对照组(P<0.05)。两组术毕时和术后12h时前列腺素E_2浓度观察组低于对照组(P<0.01);术后24h时前列腺素E_2浓度两组之间差异无显著意义(P>0.05);观察组术后24h前列腺素E_2浓度比术毕和术后12h时要高(P<0.01).结论氟比洛芬酯超前镇痛应用于全麻下扁桃体摘除术,能有效缓解术后早期疼痛,减轻炎症反应.
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| 关 键 词： | 氟比洛芬酯 超前镇痛 全麻 扁桃体摘除术 前列腺素E_2 |
The preemptive analgesia effect of flurbiprofen in the patients undergoing tonsillectomy under general anaesthesia |
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| Institution: | LONG Yun-hui TANG xin-long WU min-xian WANG ju GU hui-li WU xian-de LlU xia (Department of Anesthesiology central hospital Baoshan; Shanghai; 201900; China); |
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| Abstract: | Objective To discuss the preemptive analgesia effect of flurbiprofen in the patients undergoing tonsillectomy under general anaesthesia.Methods 60 patients with ASAI-Ⅱscheduled for tonsillectomy were randomly divided into 2 groups.GroupⅠwas injected with flurbiprofen 100mg intravenously before anaesthesia induction.GroupⅡwas as control.The VAS,soar throat and side effects associated with anaesthesia were recorded 2,6,12 and 24h after operation.The levels of PGE_2 in peripheral blood were measured at the end... |
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| Keywords: | flurbiprofen preemptive analgesia general anaesthesia tonsillectomy PGE_2 |
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