| 盐酸林可霉素的萃取与结晶提纯 |
| |
| 引用本文： | 岳晓日,钱刚,周兴贵.盐酸林可霉素的萃取与结晶提纯[J].华东理工大学学报(自然科学版),2009,35(5). |
| |
| 作者姓名： | 岳晓日 钱刚 周兴贵 |
| |
| 作者单位： | 华东理工大学化学工程联合国家重点实验室,上海,200237 |
| |
| 摘 要： | 为了降低盐酸林可霉素粗品中的B组分含量,采用萃取与结晶相结合的方法,分别研究了萃取结晶过程中萃取荆种类、用量、原料浓度、溶液pH等条件以及溶析结晶过程中的混合速率对产品纯度的影响.结果表明:丁醇或氯仿有较高的萃取效率;降低原料浓度或在萃取、反萃时分别保持溶液pH为11和5均有利于提高产品中的A组分含量;结晶过程中提高搅拌速率有利于提高产品纯度.以氯仿为萃取荆,经过单级萃取,结晶后产品中A组分纯度最高可达97.86%.
|
| 关 键 词： | 盐酸林可霉素 萃取 结晶 晶型 |
Purification of Hydrochloride Lincomycin by Solvent Extraction and Crystallization |
| |
| YUE Xiao-ri,QIAN Gang,ZHOU Xing-gui.Purification of Hydrochloride Lincomycin by Solvent Extraction and Crystallization[J].Journal of East China University of Science and Technology,2009,35(5). |
| |
| Authors: | YUE Xiao-ri QIAN Gang ZHOU Xing-gui |
| |
| Institution: | State Key Laboratory of Chemical Engineering;East China University of Science and Technology;Shanghai 200237;China |
| |
| Abstract: | To lower the content of component B in the crude lincomycin product,by means of solvent extraction combined with solvent-out crystallization,the influences of solvent, phase ratio,concentration of raw material,pH and the rate of mixing on the product purity were investigated.n-Butanol and chloroform were found to have better performance than n-pentanol,iso-pentanol,n-octanol and the mixture of chloroform with iso-pentanol or n-octanol.During extraction and reverse-extraction the pH were adjusted to 11 and 5... |
| |
| Keywords: | hydrochloride lincomycin extraction crystallization crystal form |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
