引导组织再生用心包材料体外降解规律初步研究

为了研究牛心包作为可降解生物材料在体内诱导组织再生的性能,通过用不同浓度的戊二醛交联心包后的酶解和氧化降解,对心包材料的体外降解规律做了初步探索。实验结果表明,随着交联度的增加,心包降解速率减小,耐酶解能力增强。四种酶降解实验比较显示,胰酶对心包的催化降解力最大。心包的氧化降解中,加速时间降解和实际时间降解的动态曲线呈S形,为以后建立数学模型进一步研究心包在体内的降解规律、控制降解速率、解决组织再生速率与材料降解速率相匹配等问题奠定了良好基础。

The Research on the Degradation of Bovine Pericardium in Vitro for Guiding Tissue Regeneration

Bovine pericardium is a promising nature biomaterial for its good bio-compatibility and degradative property. The degradation rule of bovine pericardium in vitro was investigated by using different crosslinking-degree pericardium for enzymolysis and oxidation experiments. The higher the crosslinking-degree, the stronger the anti-degrade ability was. Trypsin is the most effective in four kinds of enzymes for degradation. The shape of "S" curves were obtained in the oxidation degradation, which may be a useful base of a mathematic model for the further research on the degradation of bovine pericardium.