Experiments on the mechanism of the inhibition of mitochondrial Ca2+ transport by La3+ and ruthenium red |
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Authors: | Verena Niggli P. Gazzotti E. Carafoli |
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Affiliation: | (1) Laboratory of Biochemistry, Swiss Federal Institute of Technology (ETH), CH-8092 Zurich, (Switzerland) |
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Abstract: | Summary The effects of La3+ and ruthenium red on the energy-linked uptake of Ca2+ mediated by a synthetic neutral Ca2+ ionophore have been investigated in rat liver mitochondria. The results indicate that unspecific surface charge effects do not play a major role in the mechanism of inhibition of mitochondrial Ca2+ transport by La3+ and ruthenium red.Acknowledgments. The authors are indebted to Prof. W. Simon, ETH Zurich, for having provided samples of the synthetic neutral Ca2+ ligand, and to M. Mattenberger for the valuable technical assistence. The work was supported by a grant of the Swiss Nationalfonds (grant No. 3.1720.75). |
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