Suppressed collagenolytic activity in polymorphonuclear leucocytes from diabetic humans |
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| Authors: | G A Nicoll G M Gollapudi N S Ramamurthy L M Golub |
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| Institution: | (1) School of Dental Medicine, State University of New York at Stony Brook, 11794 Stony Brook, New York, USA;(2) Veterans Administration Hospital, Northport, New York, USA |
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| Abstract: | Summary Extracts of polymorphonuclear leucocytes (PMNL) from diabetic human exhibited less collagenolytic activity than extracts from normoglycemic control subjects. Partially purified control extracts produced  A and B collagen breakdown products of the type generated by mammalian collagenase; the diabetic preparation produced decreased amounts of the same products. The diabetic PMNLs may synthesize abnormally low levels of collagenase or contain inactive forms of this enzyme.Supported by a grant (No. DE-03987) from the National Institute of Dental Research (N.I.H.), USA. This study forms part of the Ph.D. thesis of G.A. Nicoll.Acknowledgments. The authors wish to thank Ms Salema Karim and Mr F.R. Singh for excellent technical assistance. |
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