| 2-氨基-1,3,4-噻二唑合成新方法 |
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| 引用本文： | 郑浩,董慧民,丁呈华,冶保献.2-氨基-1,3,4-噻二唑合成新方法[J].河南师范大学学报(自然科学版),2006,34(2):68-70. |
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| 作者姓名： | 郑浩 董慧民 丁呈华 冶保献 |
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| 作者单位： | 郑州大学,化学系,郑州,450052 |
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| 摘 要： | 首次以草酸为原料在盐酸催化下一步合成了2-氨基-1,3,4-噻二唑,产品的纯度达到99%(HPLC)以上,并通过IR1、3C NMR、高分辨MS等手段对其结构进行了表征.实验结果表明,该合成路线具有反应条件温和、收率高、操作简单、对环境安全友好等特点.与甲酸相比,草酸价格更便宜,这种方法不仅降低了生产成本,而且易于工业化生产.
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| 关 键 词： | 2-氨基-1 3 4-噻二唑 制备 表征 |
| 文章编号： | 1000-2367(2006)02-0068-03 |
| 收稿时间： | 2005-12-17 |
| 修稿时间： | 2005年12月17 |
A New Method for Synthesis of 2-Amino-1,3,4-Thiadiazole |
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| ZHENG Hao,DONG Hui-min,DING Cheng-hua,YE Bao-xian.A New Method for Synthesis of 2-Amino-1,3,4-Thiadiazole[J].Journal of Henan Normal University(Natural Science),2006,34(2):68-70. |
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| Authors: | ZHENG Hao DONG Hui-min DING Cheng-hua YE Bao-xian |
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| Institution: | Department of Chemistry, Zhengzhou University, Zhengzhou 450052,China |
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| Abstract: | 2-amino-1,3,4-thiadiazole was synthesized by reaction of aminothiourea with oxalic acid in the presence of hydrochloric acid as catalyst in one step.The purity of the product is higher than 99%(HPLC).Its structure was characterized by IR,~(13)C NMR and HRMS.It is testified that the facile synthetic scheme put forward in this work has the characteristics of mild reaction condition,high yield,simple operation and being environmentally-friendly.Compared with formic acid,oxalic acid is cheaper,and the cost is reduced;a scale production can be achieved. |
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| Keywords: | 2- amino- 1 3 4- thiadiazole synthesis characterization |
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