Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical,biochemical and electrophysiological parameters in the mammalian heart |
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Authors: | R. Brückner S. Gramann M. Nose W. Schmitz H. Scholz |
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Affiliation: | (1) Abteilung Allgemeine Pharmakologie, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Martinistrasse 52, D-2000 Hamburg 20, Germany |
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Abstract: | Summary The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) mimicked the effects of isoprenaline on the force of contraction, the cAMP content and the slow Ca++ inward current (Isi) in isolated guinea pig papillary muscles. The results support the hypothesis that phosphodiesterase inhibitors and -adrenoceptor agonists exert their positive inotropic effects by increasing Isi via the common mediator cAMP.Acknowledgment. This work was supported by the Deutsche Forschungsgemeinschaft. |
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Keywords: | 3-Isobutyl-1-methylxanthine guinea pig heart phosphodiesterase inhibitor isoprenaline slow inward current positive inotropic effect cAMP cGMP |
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