| 急性肝功能衰竭的猪动物模型 |
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| 引用本文： | 陈影波,何永源,杜原赞,邬艳红,杨振帆,范上达. 急性肝功能衰竭的猪动物模型[J]. 暨南大学学报(自然科学与医学版), 2000, 21(6): 22-25 |
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| 作者姓名： | 陈影波 何永源 杜原赞 邬艳红 杨振帆 范上达 |
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| 作者单位： | 1. 暨南大学医学院第一附属医院外科，广东广州 510630
2. 香港大学外科，香港 |
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| 摘 要： | 目的：建立一个比较接近人类条件的急性肝衰竭模型。用于人工肝脏治疗的疗效和安全性的测试。方法：以右旋半乳糖来制造猪肝衰竭的大型动物模型，分组３组给药，剂量分别为０．５、１和０．７５g/kg。观察其临床表现、生理生化指标和病理改变。结果：３组实验都能引出与人的临床和生化指标变化相伫的肝功能衰竭的表现，以０．７５g/kg组最为理想。结论：以０．７５g/kg的半乳糖胺制造的急性肝功能衰竭的猪动物模型，符合人工肘脏研究对动物模型的要求。
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| 关 键 词： | 肝功能衰竭 猪 动物模型 人工肝脏支持 |
| 文章编号： | 1000-9965(2000)06-0022-04 |
| 修稿时间： | 2000-10-15 |
A pig animal model of fulminant hepatic failure |
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| CHEN Ying-bo,David Ho,Jensen To,Jana Wo,YANG Zheng-fan,Fan ST. A pig animal model of fulminant hepatic failure[J]. Journal of Jinan University(Natural Science & Medicine Edition), 2000, 21(6): 22-25 |
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| Authors: | CHEN Ying-bo David Ho Jensen To Jana Wo YANG Zheng-fan Fan ST |
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| Abstract: | Aim: To establish a clinically relevant model of fulminant hepatic failure for the test of efficacy and safety of artificial liver support. Methods: We induced a pig model of fulminant hepatic failure by administration of D-galactosamine in the dosage of 0.5 g/kg, 0.75 g/kg and 1 g/kg, and observed the clinical manifestations, biochemical and pathological changes of the diseased pigs. Results: D-galactosamine in the three dosages was able to induce a hepatic failure model, but the dosage of 0.75 g/kg is most suitable for the studies of artificial liver support. Conclusion: A large animal model of fulminant hepatic failure that closely mimics the clinical situation was established. [ |
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| Keywords: | hepatic failure large animal model artificial liver support |
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