| 单向白蛋白透析滤过对模拟肝衰竭患者血浆的净化作用 |
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| 引用本文： | 龚晓兵,杨冬华,韦宏成,杨见权,汤绍辉. 单向白蛋白透析滤过对模拟肝衰竭患者血浆的净化作用[J]. 暨南大学学报(自然科学与医学版), 2007, 28(2): 160-163 |
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| 作者姓名： | 龚晓兵 杨冬华 韦宏成 杨见权 汤绍辉 |
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| 作者单位： | 暨南大学附属第一医院消化内科人工肝室,广东,广州,510630;暨南大学附属第一医院消化内科人工肝室,广东,广州,510630;暨南大学附属第一医院消化内科人工肝室,广东,广州,510630;暨南大学附属第一医院消化内科人工肝室,广东,广州,510630;暨南大学附属第一医院消化内科人工肝室,广东,广州,510630 |
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| 基金项目： | 广东省科学技术厅-广东省粤港地区重大领域项目 |
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| 摘 要： | 目的:观察单向白蛋白透析滤过技术对模拟肝衰竭患者血浆的净化作用.方法:利用单向白蛋白透析滤过或持续性静-静脉血液透析滤过处理含有一定浓度代谢产物的血浆,检测治疗前后血浆中胆红素,胆汁酸,氨,尿素和肌酐浓度,并利用SPSS 10.0软件进行统计学分析.结果:单向白蛋白透析滤过可显著降低血浆胆红素水平,而持续性静-静脉血液透析滤过对胆红素水平无显著影响.胆汁酸的降低幅度在单向白蛋白透析滤过组显著高于持续性静-静脉血液透析滤过组.两种方法对水溶性代谢产物氨、尿素和肌酐的清除作用相似.结论:单向白蛋白透析滤过清除血浆中白蛋白结合物质的作用强于持续性静-静脉血液透析滤过,对水溶性物质的清除,二者作用相似.
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| 关 键 词： | 白蛋白透析滤过 肝衰竭 肝 人工 |
| 文章编号： | 1000-9965(2007)02-0160-04 |
| 修稿时间： | 2006-04-10 |
The study of the purification function of single-pass albumin diafiltration (SPADF) in vitro |
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| GONG Xiao-bing,YANG Dong-hua,WEI Hong-cheng,YANG Jian-quan,TANG Shao-hui. The study of the purification function of single-pass albumin diafiltration (SPADF) in vitro[J]. Journal of Jinan University(Natural Science & Medicine Edition), 2007, 28(2): 160-163 |
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| Authors: | GONG Xiao-bing YANG Dong-hua WEI Hong-cheng YANG Jian-quan TANG Shao-hui |
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| Affiliation: | Department of Gastroenterology, First Affiliated Hospital, Jinan University, Guangzhou 510630, China |
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| Abstract: | Aim:To evaluate the detoxication capacities of single-pass albumin diafiltration(SPADF) in vitro. Methods: In each experiment quantitative toxin-loaded human plasma was processed by SPADF or CVVHDF.Levels of bilirubin,bile acids,ammonia, urea and creatinine were determined.Concentrations before and after application of detoxication procedures were expressed as differences and were compared using the SPSS 10.0 software.Results: SPADF induced a significant reduction in bilirubin levels than CVVHDF.SPADF induced a signicantly reduction of bile acid levels than CVVHDF.No significant differences were found between SPADF and CVVHDF with respect to other water-soluble substances.Conclusion:The detoxication capacity of SPADF for albumin-bounding substances is stronger than that of CVVHDF. |
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| Keywords: | albumin diafiltration liver failure liver artificial |
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