| SMM混悬注射液对靶动物的安全性试验研究 |
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| 引用本文： | 吴莉萍,吴俊伟,宋小鸿. SMM混悬注射液对靶动物的安全性试验研究[J]. 西南民族学院学报(自然科学版), 2006, 32(5): 966-970 |
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| 作者姓名： | 吴莉萍 吴俊伟 宋小鸿 |
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| 作者单位： | 内江职业技术学院 内江641100(吴莉萍)，西南大学荣昌校区动物医学系 重庆402460(吴俊伟)，重庆方通动物药业有限公司创新兽药研究所 重庆402460(宋小鸿) |
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| 摘 要： | 目的评价磺胺间甲氧嘧啶(Sulfamonomethoxine,SMM)混悬注射液对靶动物的安全性.方法选择16头健康长×荣杂交猪,随机分成2个不同剂量组和1个空白对照组,剂量组每组6头,深部肌内分点注射给药,对照组4头注射生理盐水,连续观察,记录其对动物的体温、WBC、RBC、HB等影响情况.结果500 mg/kg体重剂量组除产生局部刺激外,无其他明显毒性反应;1000 mg/kg体重剂量组出现中毒表现,其中毒损伤的器官主要是肝脏和肾脏.结论应用磺胺间甲氧嘧啶不超过500mg/kg体重剂量时,临床用药安全.
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| 关 键 词： | 磺胺间甲氧嘧啶 靶动物 安全性试验 |
| 文章编号： | 1003-2843(2006)05-0966-05 |
| 修稿时间： | 2006-07-18 |
Safety test of Sulfamonomethoxine Suspensions Injection on the target animal |
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| WU Li-ping,WU Jun-wei,SONG Xiao-hong. Safety test of Sulfamonomethoxine Suspensions Injection on the target animal[J]. Journal of Southwest Nationalities College(Natural Science Edition), 2006, 32(5): 966-970 |
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| Authors: | WU Li-ping WU Jun-wei SONG Xiao-hong |
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| Abstract: | Objective: To evaluate the safety of Sulfamonomethoxine Suspensions Injection used on the target animal.Methods: 16 Landrace Rongchang crossbred pigs are divided into 3 groups at random.There are 6 pigs in the dosage of 500 mg/kg group and 6 pigs in the dosage of 1000 mg/kg group,and the rest in non-drugs group.Giving drugs to the pigs one time at several deep sites and observe the influence situation of body temperature,WBC,RBC,HB and so on constantly.Results: There is not significant damage in the dosage of 500 mg/kg group except partial stimulus.Certain damage is in the dosage of 1000 mg/kg group and the organs of toxic mainly are livers and kidneys.Conclusion: It is safe to use Sulfamonomethoxine Suspensions Injection under the dosage of 500 mg/kg. |
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| Keywords: | Sulfamonomethoxine Suspensions Injection target animal safety test |
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