| 双(2-甲氧乙氧基)铝氢化钠还原芳杂环酯的研究 |
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| 引用本文： | 靳立人,刘宝丽,时晓军,沈阳,谭斌.双(2-甲氧乙氧基)铝氢化钠还原芳杂环酯的研究[J].厦门大学学报(自然科学版),2004,43(3):352-355. |
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| 作者姓名： | 靳立人 刘宝丽 时晓军 沈阳 谭斌 |
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| 作者单位： | 厦门大学化学系,福建省化学生物学重点实验室,福建,厦门,361005 |
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| 摘 要： | 双(2 甲氧乙氧基)铝氢化钠还原5 噻唑甲酸乙酯和3 吡啶甲酸乙酯,分别得到重要的医药中间体5 羟甲基噻唑和3 羟甲基吡啶.比较了反应温度,反应时间,还原剂当量比以及后处理方法等因素对反应的影响.5 噻唑甲酸乙酯还原收率为72%,3 吡啶甲酸乙酯还原收率为93.9%.
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| 关 键 词： | 双(2-甲氧乙氧基)铝氢化钠 5-羟甲基噻唑 3-羟甲基吡啶 |
| 文章编号： | 0438-0479(2004)03-0352-04 |
| 修稿时间： | 2003年5月29日 |
Reduction of Heterocyclic Carboxylic Acid Ester with bis-Methoxyethoxyaluminum Hydride |
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| JIN Li-ren,LIU Bao-li,SHI Xiao-jun,SHEN Yang,TAN BinChemical Biology,Xiamen Univ.,Xiamen ,China.Reduction of Heterocyclic Carboxylic Acid Ester with bis-Methoxyethoxyaluminum Hydride[J].Journal of Xiamen University(Natural Science),2004,43(3):352-355. |
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| Authors: | JIN Li-ren LIU Bao-li SHI Xiao-jun SHEN Yang TAN BinChemical Biology Xiamen Univ Xiamen China |
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| Institution: | JIN Li-ren,LIU Bao-li,SHI Xiao-jun,SHEN Yang,TAN BinChemical Biology,Xiamen Univ.,Xiamen 361005,China) |
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| Abstract: | Ethyl 5-thiazolecarboxylate and ethyl 3-pyridinecarboxylate are reduced with sodium bis(2-methoxyethoxy)aluminum hydride to give 5-hydroxymethylthiazole and 3-hydroxymethylpyridine, which are two useful pharmaceutical intermediates, respectively, with 72% and 93.9% yield. Some test results in different reaction conditions, such as reaction time, temperature, ratio of reducing agent to substrates and work-up methods, are investigated. |
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| Keywords: | sodium bis(2-methoxyethoxy)aluminum hydride 5-hydroxymethylthiazole 3-hydroxymethylpyridine |
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