| 高效液相色谱法测定盐酸利多卡因贴剂含量 |
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| 引用本文： | 柯光明,王丽,杜洪光,王树明,郭洪猷. 高效液相色谱法测定盐酸利多卡因贴剂含量[J]. 北京化工大学学报(自然科学版), 2004, 31(5): 110-112 |
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| 作者姓名： | 柯光明 王丽 杜洪光 王树明 郭洪猷 |
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| 作者单位： | 北京化工大学理学院,北京,100029;北京康倍得医药技术开发有限公司,北京,100089 |
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| 摘 要： | 文中建立了盐酸利多卡因贴剂含量的测定方法。用Waters公司XterraC18柱 (5μm,3.9mm×150mm),流动相为甲醇0.05mol·L-1的碳酸氢铵水溶液(用氨水调节pH =8.5 0,体积比为50∶50) ,流速10mL·min-1。结果显示盐酸利多卡因在20～640mg·L-1范围内呈现良好的线性关系,r值为 0.9998。利多卡因回收率为99.77%,RSD为0.68%。本方法简单、灵敏、准确,可作为该制剂内在质量的控制方法。
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| 关 键 词： | 高效液相色谱 盐酸利多卡因 贴剂 |
| 修稿时间： | 2004-02-23 |
Measurement of lidocaine hydrochloride in patch by HPLC |
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| Ke Guang-ming Wang Li Du Hong-guang Wang Shu-ming Guo Hong-you. Measurement of lidocaine hydrochloride in patch by HPLC[J]. Journal of Beijing University of Chemical Technology, 2004, 31(5): 110-112 |
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| Authors: | Ke Guang-ming Wang Li Du Hong-guang Wang Shu-ming Guo Hong-you |
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| Affiliation: | 1.College of Science; Beijing University of Chemical Technology; Beijing; 2.Beijing KBD Pharmaceutical Technology Development Ltd; China |
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| Abstract: | A high performance liquid chromatography(HPLC) method for the measurement of lidocaine hydrochloride in patch was developed. It was performed by using XterraC18 column (5μm, 3.9mm×150mm). The mobile phase, consisting of methanol -0.05mol·L -1 ammonium hydrogen carbonate solution (50∶50, v/v) adjusted to pH=8.50 with ammonia solution, was maintained to a flow-rate of 1.0mL·min -1 . The calibration curve had a good linearity in the range of 20～640mg·L -1 . The average recovery was 99.77% and RSD was 0.68%.This method was simple,sensitive and accurate.It can be used for the quality control of the patch. |
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| Keywords: | HPLC lidocaine hydrochloride patch |
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