| 二烃基锡N-(5-氯亚水杨醛基)-L-异亮氨酸酯的合成、结构及抑菌活性 |
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| 引用本文： | 刘念丽,张纪云,于菲,于游,田来进.二烃基锡N-(5-氯亚水杨醛基)-L-异亮氨酸酯的合成、结构及抑菌活性[J].曲阜师范大学学报,2010,36(2):92-96. |
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| 作者姓名： | 刘念丽 张纪云 于菲 于游 田来进 |
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| 作者单位： | 刘念丽,张纪云,于菲,于游(曲阜师范大学化学与化工学院,273165,曲阜市);田来进(曲阜师范大学化学与化工学院,273165,曲阜市;山东大学化学与化工学院,250100,山东省济南市) |
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| 基金项目： | 山东省博士后创新项目专项资金，山东大学胶体与界面化学教育部重点实验室开放基金，国家自然科学基金 |
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| 摘 要： | 利用二烃基二氯化锡和新制的N-(5-氯亚水杨醛基)-L-异亮氨酸反应合成了三个新的二烃基锡N-(5-氯亚水杨醛基)-L-异亮氨酸酯,R2Sn2-O-5-C lC6H3CH=NCH(s-Bu)COO](R=Ph,1;c-C6H11,2;n-Bu,3),通过元素分析、IR、1H NMR及X-射线单晶衍射分析表征了其结构.化合物1属单斜晶系,P21空间群,中心锡原子具有畸变的三角双锥构型,与三齿配体形成了五元和六元两个螯合环.生物活性测试表明,合成的三种化合物对大肠杆菌和金黄色葡萄球菌均有良好的抑制作用.
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| 关 键 词： | 有机锡羧酸酯 异亮氨酸 抑菌活性 晶体结构 |
Synthesis,Structure and Anti-bacterial Activity of Dialkyltin N-(5-Chlorosalicylidene)-L-isoleucinates |
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| LIUNian-Li%e%%a,ZHANGJi-Yun%e%%a,YUFei,YUYou%e%%aTIANLai-Jin%e%%a%e%%a.Synthesis,Structure and Anti-bacterial Activity of Dialkyltin N-(5-Chlorosalicylidene)-L-isoleucinates[J].Journal of Qufu Normal University(Natural Science),2010,36(2):92-96. |
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| Authors: | LIUNian-Li%e%%a ZHANGJi-Yun%e%%a YUFei YUYou%e%%aTIANLai-Jin%e%%a%e%%a |
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| Institution: | LIU+Nian-Li%e2%91%a0,ZHANG+Ji-Yun%e2%91%a0,YU+Fei,YU+You%e2%91%a0+TIAN+Lai-Jin%e2%91%a0%e2%91%a1(%e2%91%a0School+of+Chemistry+,+Chemical+Engineering,Qufu+Normal+University,273165,Qufu,%e2%91%a1School+of+Chemistry+,+Chemical+Engineering,Sh,ong+University,250100,Jinan,Sh,ong,PRC) |
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| Abstract: | Three new dialkyltin N-(5-Chlorosalicylidene)-L-isoleucinates,R2Sn2-O-5-ClC6H3CH=NCH(s-Bu)COO](R = Ph,1;c-C6H11,2;n-Bu,3) were synthesized by the reaction of dialkyltin dichloride with in situ formed potassium N-(5-chlorosalicylidene)-L-isoleucinate and characterized by elemental analysis,IR,1H NMR.The structure of 1 has been determined by X-ray crystallography.The crystal of 1 is monoclinic space group P21 and tin atom is in a distorted trigonal bipyramidal geometry to form five-and six-membered chelate r... |
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| Keywords: | organotin carboxylate isoleucine antibacterial activity crystal structure |
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