Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell |
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Authors: | Akira Kudo |
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Institution: | (1) Department of Biological Information, Tokyo Institute of Technology, Yokohama 226-8501, Japan |
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Abstract: | More than 10 years have passed since the naming of periostin derived from its expression sites in the periosteum and periodontal
ligament. Following this finding, we have accumulated more data on the expression patterns of periostin, and, finally, with
the generation of periostin-deficient mice, have revealed functions of periostin in the regeneration of tissues in bone, tooth,
heart, and skin, and its action in cancer invasion. Since periostin is a matricellular protein, the first investigation of
periostin function showed its enhancement of cell migration by acting outside the cell. On the other hand, recent observations
have demonstrated that periostin functions in fibrillogenesis in association with extracellular matrix molecules inside the
cell. |
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Keywords: | |
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