Stimulation of cyclo-oxygenase by lidocaine,a pro-lipoperoxidant |
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Authors: | C Deby G Deby-Dupont P Hans J Pincemail J Bourdon-Neuray |
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Institution: | (1) Laboratoire de Biochimie Appliquée, Faculté de Médecine, Université de Liège, Blvd. de la Constitution, 32, B-4020 Liège, (Belgium) |
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Abstract: | Summary Lidocaine, which was recently demonstrated to be a good pro-lipoperoxidant, was tested on in vitro PGs biosynthesis, and on arachidonate-induced arterial hypotension, in the rabbit. In the in vitro experiments, lidocaine alone was a poor stimulant of cyclo-oxygenase, but it enhanced significantly the cyclo-oxygenase activation of uric acid. In the rabbit, lidocaine lowered the i.v. arachidonate dose necessary to obtain a significant drop of blood pressure. |
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