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Stimulation of cyclo-oxygenase by lidocaine,a pro-lipoperoxidant
Authors:C Deby  G Deby-Dupont  P Hans  J Pincemail  J Bourdon-Neuray
Institution:(1) Laboratoire de Biochimie Appliquée, Faculté de Médecine, Université de Liège, Blvd. de la Constitution, 32, B-4020 Liège, (Belgium)
Abstract:Summary Lidocaine, which was recently demonstrated to be a good pro-lipoperoxidant, was tested on in vitro PGs biosynthesis, and on arachidonate-induced arterial hypotension, in the rabbit. In the in vitro experiments, lidocaine alone was a poor stimulant of cyclo-oxygenase, but it enhanced significantly the cyclo-oxygenase activation of uric acid. In the rabbit, lidocaine lowered the i.v. arachidonate dose necessary to obtain a significant drop of blood pressure.
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