New amino sugar analogues are incorporated at different rates into glycoproteins of mouse organs |
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Authors: | H. Kayser C. Ats J. Lehmann W. Reutter |
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Affiliation: | (1) Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, D-14195 Berlin, (Dahlem), (Germany);(2) Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104 Freiburg, (Germany) |
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Abstract: | Different radiolabelled N-acyl-derivatives of D-glucosamine were synthesized using D-glucosamine and the respective carbonic acid anhydride. Metabolism of these sugar analogues could be shown in vitro as well as in vivo. After the intraperitoneal administration of these radiolabelled N-acyl-D-glucosamines to mice, their rate of incorporation into glycoproteins of different organs was found to increase markedly with the length of the N-acyl side chain. Highest incorporation was measured in the whole intestine using N-pentanoyl-D-glucosamine as label. |
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Keywords: | Amino sugar analogues liver intestine glycoproteins |
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