Amiloride impairs the cholinergic regulation of potassium permeability in the human sweat gland but not in the rat submandibular gland |
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Authors: | S M Wilson J D Pediani D McE Jenkinson H Y Elder |
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Institution: | 1. The Institute of Physiology, University of Glasgow, G12 8QQ, Glasgow, (Scotland)
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Abstract: | Potassium permeability was monitored in human sweat glands and rat submandibular glands. Acetylcholine increased permeability in both tissues and the responses consisted of transient, calcium-independent and sustained, calcium-dependent components. Amiloride, a drug which inhibits Na+?H+ countertransport, impaired the regulation of potassium permeability in sweat glands but not in the submandibular gland. It is suggested that the stimulus-permeability coupling process in the sweat gland may be sensitive to the lowering of internal pH. |
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