Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice |
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| Authors: | M Ishikawa M Ozaki Y Takayanagi K Sasaki |
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| Institution: | 1. Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, 4-4-1 Komatsushima, Aoba-ku, 981, Sendai, (Japan)
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| Abstract: | The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice. |
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