兔膝关节骨关节炎模型建立的探讨 |
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引用本文: | 陈康,;陈泽俊,;符红娜,;程凌枫,;欧毅,;黄垂灿. 兔膝关节骨关节炎模型建立的探讨[J]. 实验动物科学, 2014, 31(5): 33-35 |
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作者姓名: | 陈康, 陈泽俊, 符红娜, 程凌枫, 欧毅, 黄垂灿 |
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作者单位: | [1]海南医学院临床学院; [2]海南医学院附属医院,海南海口571101 |
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基金项目: | 国家级大学生创新创业项目(No.201311810045); 海南医学院大学生创新性实验计划项目(No.HYCX201212). |
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摘 要: | 摘要: 目的 探讨应用前交叉韧带和内外侧半月板切除的方法制作骨关节炎( OA) 动物模型的可行性及可靠性。 方法 成年雄性新西兰大白兔 20 只,于右后肢膝关节切断前交叉韧带和切除内外侧半月板,左后肢仅打开关节 囊,不对关节内部进行操作,观察术后兔子活动情况; 于第 2、6、10 周处死,观察其左、右两侧后肢膝关节软骨病理 改变。实验动物 2、6、10 周后取右后肢膝关节软骨为实验组,左侧肢体膝关节软骨标本为对照组,比较两组软骨病 变情况。结果 2、6、10 周后,从实验动物活动表现和大体标本观察,兔右后肢膝关节均呈典型的 OA 特征。结论 前交叉韧带和内外侧半月板切除是一个制作 OA 动物模型的较为理想的方法。
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关 键 词: | 骨关节炎 动物模型 前交叉韧带 半月板 |
Investigation on the Establishment of Rabbit Knee Osteoarthritis Model |
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Affiliation: | CHEN Kang, CHEN Ze-jun, FU Hong-na, CHENG Ling-feng, OU Yi,HUANG Chui-can( 1. Clinical Institute of Hainan Medical University, Haikou 571101, China;2. Affiliated Hospital of Hainan Medical University, Haikou 571101, China) |
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Abstract: | Objective To explore the feasibility and reliability of application of anterior cruciate ligament and the medial and lateral meniscus resection of making animal model of OA. Method 20 adult male New Zealand rabbits ,on the right leg knee cut off the anterior erueiate ligament and excision of medial and lateral meniscus,just open the left hind limb joint capsule,no joint operation,observation of postoperative rabbit activities ; In 2, 6, 10 weeks later, observation the left, right posterior articular cartilage pathology. After 2, 6, 10 weeks, the right leg knee cartilage as the experimental group, the left limb knee joint cartilage were as control group, comparison of two groups of cartilage lesions. Result 2, 6, 10 weeks later, from the experimental animal activity and gross specimen observation, rabbit right leg knee showed the typical characteristics of OA. Conclusion anterior cruciate ligament and the medial and lateral meniscus resection is an ideal method for a OA animal model making. |
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Keywords: | osteoarthritis animal model anterior cruciate ligament meniscus |
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