Use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin,oxytocin and DDAVP in rats after prolonged infusion of DDAVP |
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| Authors: | S Lundin P Melin H Vilhardt |
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| Institution: | (1) Institute of Zoophysiology, University of Lund, S-22362 Lund, (Sweden);(2) Ferring Pharmaceuticals, Box 30561, S-20062 Malmö, (Sweden);(3) Department of Medical Physiology C, University of Copenhagen, DK-2200 N Copenhagen, (Denmark) |
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| Abstract: | Summary Specific radioimmunoassays (RIA) were employed for measuring plasma and neurohypophysial concentrations of oxytocin (OT) and vasopressin (AVP) after administration of 1-deamino-8-D-Arg-vasopressin (DDAVP). DDAVP concentrations were measured by a newly-developed specific RIA. Through the use of minipumps, DDAVP was infused i.p. over a period of 3 days in normally hydrated rats. Despite decreased urine production and increased urine osmolality no changes could be observed in neurohypophysial and plasma hormone concentrations. |
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| Keywords: | Radioimmunoassay oxytocin vasopressin neurohypophysis |
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