The action of conformationally restricted analogues of GABA onLimulus andHelix central neurones |
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| Authors: | Victoria A James P Krogsgaard-Larsen R J Walker |
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| Institution: | (1) Department of Physiology and Biochemistry, University of Southampton, S09 3TU Southampton, (England);(2) Department of Chemistry BC, Royal School of Pharmacy, DK-2100 Copenhagen, (Denmark) |
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| Abstract: | Summary Intracellular recordings have been made from GABA sensitive neurones in the central nervous system ofLimulus andHelix. The following conformationally restricted analogues of GABA all possessed GABA-like activity onLimulus neurones andHelix excitatory GABA receptors: muscimol, thiomuscimol, THIP, isoguvacine and piperidine-4-carboxylic acid. It is suggested that GABA interacts with these receptors in a partially extended and almost planar conformation. |
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