Prolactin and growth hormone signal transduction in lymphohaemopoietic cells |
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| Authors: | L-y Yu-Lee G Luo S Moutoussamy J Finidori |
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| Institution: | (1) Department of Medicine, Baylor College of Medicine, Houston (Texas 77030, USA), Fax +1 713 798 5780, e-mail: yulee@bcm.tmc.edu, US;(2) Department of Cell Biology, Baylor College of Medicine, Houston (Texas 77030, USA), US;(3) Department of Microbiology and Immunology, Baylor College of Medicine, Houston (Texas 77030, USA), US;(4) INSERM, Paris (France), FR |
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| Abstract: | The peptide hormones, prolactin (PRL) and growth hormone (GH), are known to regulate numerous target tissues. Among such
targets are cells of the immune system, including T cells, B cells, macrophages and natural killer cells. We have cloned a
panel of PRL- and GH-inducible T cell genes for use in studies to understand how these hormones through the expression of
these genes modulate the biology of immune function cells. This article focuses on the signalling pathways emanating from
the PRL receptor (PRL-R) and GH receptor (GH-R), and the expression of PRL-inducible target genes. |
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| Keywords: | , Prolactin, growth hormone, receptor, signal transduction, STAT, IRF-1, |
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