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Cyclic CMP (cytidine 3′,5′-monophosphate) suppresses changes in human sperm amplitude of lateral head displacement and hyperactivation |
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| Authors: | P J Chan D R Tredway I Henig S G Prough |
| Institution: | (1) Dept of Gynecology and Obstetrics, Loma Linda University School of Medicine, 92 354 Loma Linda, (California), (USA);(2) Hillcrest Fertility Center and Dept of Obstetrics and Gynecology, Oral Roberts University, 74 104 Tulsa, (Oklahoma), (USA);(3) Hillcrest Fertility Center, 74 104 Tulsa, (Oklahoma), (USA) |
| Abstract: | Summary The dibutyryl analog of cCMP suppressed sperm amplitude of lateral head displacement and hyperactivation. Sperm motility was inhibited by dibutyryl cCMP with a shift toward less linear trajectory sperm movements. The results suggest a role of cCMP as an inhibitory signal on sperm motility patterns related to sperm capacitation. |
| Keywords: | cCMP sperm motility capacitation videomicrograph |
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