Maternal stress alters monoamine metabolites in fetal and neonatal rat brain |
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| Authors: | L. R. Herrenkohl U. Ribary M. Schlumpf W. Lichtensteiger |
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| Affiliation: | (1) Department of Psychology, Temple University, 19122 Philadelphia, Pennsylvania, USA;(2) Pharmakologisches Institut, University of Zürich, CH-8006, Switzerland |
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| Abstract: | Summary Heat-restraint stress given rats during the last week of gestation significantly altered dopaminergic dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA) and noradrenergic 3-methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG) forebrain-hypothalamic monoamine (MA) metabolites in female offspring. On gestational day 21, HVA and MOPEG were significantly higher and lower, and on postnatal day 1 all were higher. There were virtually no differences in brain MA concentrations in males. Thus MA metabolic concentrations differ in fetal-neonatal forebrain-hypothalamus as a function of sex differences and maternal stress. |
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| Keywords: | Maternal stress monoamine metabolites perinatal rat brain |
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