| Extraction of penicillin G by aqueous two-phase system of [Bmim]BF4/NaH2PO4 |
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| 引用本文： | LIU Qingfen HU Xuesheng WANG Yuhong YANG Ping XIA Hansong YU Jiang LIU Huizhou. Extraction of penicillin G by aqueous two-phase system of [Bmim]BF4/NaH2PO4[J]. 科学通报(英文版), 2005, 50(15): 1582-1585. DOI: 10.1360/982004-367 |
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| 作者姓名： | LIU Qingfen HU Xuesheng WANG Yuhong YANG Ping XIA Hansong YU Jiang LIU Huizhou |
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| 作者单位： | [1]Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering,Chinese Academy of Sciences, Beijing 100080, China [2]Graduate School of the Chinese Academy of Sciences, Beijing 100039,China [3]North China Pharmaceutical Group, Shijiazhuang 050015, China |
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| 摘 要： | A novel approach for the extraction of penicillin G by aqueous two-phase system comprised of hydrophilic ionic liquid [Bmim]BF4 （1-butyl-3-methylimidazolium tetrafluoroborate） and NaH2PO4 is reported. The effects of some important parameters involving the concentration of NaH2PO4, the concentration of penicillin G, the amount of [Bmim]BF4 on the formation of aqueous two-phase system and the extraction yield of penicillin were investigated. The primary result shows that the ATPS can take advantage of penicillin concentrated in upper phase at higher pH value for penicillin extraction from its aqueous solution without emulsification.
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| 关 键 词： | 青霉素 萃取法 吸水离子 二相系统 硝酸盐 |
| 收稿时间： | 2004-09-23 |
| 修稿时间： | 2004-09-232004-12-24 |
Extraction of penicillin G by aqueous two-phase system of [Bmim]BF4/NaH2PO4 |
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| Liu Qingfen,Hu Xuesheng,Wang Yuhong,Yang Ping,Xia Hansong,Yu Jiang,Liu Huizhou. Extraction of penicillin G by aqueous two-phase system of [Bmim]BF4/NaH2PO4[J]. Chinese science bulletin, 2005, 50(15): 1582-1585. DOI: 10.1360/982004-367 |
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| Authors: | Liu Qingfen Hu Xuesheng Wang Yuhong Yang Ping Xia Hansong Yu Jiang Liu Huizhou |
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| Affiliation: | LIU Qingfen1,2,3, HU Xuesheng1,2, WANG Yuhong3, YANG Ping3, XIA Hansong1,2, YU Jiang1 & LIU Huizhou1 1. Laboratory of Separation Science and Engineering, State Key Labora-tory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China; 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China; 3. North China Pharmaceutical Group, Shijiazhuang 050015, China |
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| Abstract: | A novel approach for the extraction of penicil-lin G by aqueous two-phase system comprised of hydrophilic ionic liquid [Bmim]BF4 (1-butyl-3- methylimidazolium tetra-fluoroborate) and NaH2PO4 is reported. The effects of some important parameters involving the concentration of NaH2PO4, the concentration of penicillin G, the amount of [Bmim]BF4 on the formation of aqueous two-phase system and the extraction yield of penicillin were investigated. The primary result shows that the ATPS can take advantage of penicillin concentrated in upper phase at higher pH value for penicillin extraction from its aqueous solution without emul-sification. |
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| Keywords: | ionic liquid phosphate aqueous two-phase penicillin G extraction. |
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