| 小鼠避暗实验三种训练方法的效果比较 |
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| 引用本文： | 廖艺聪,李艳,王雷,王亚祥,赵冰雪,邓倩,谈艳雯,刘强,严涛,孟晶.小鼠避暗实验三种训练方法的效果比较[J].井冈山大学学报（自然科学版）,2011(4):101-103. |
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| 作者姓名： | 廖艺聪 李艳 王雷 王亚祥 赵冰雪 邓倩 谈艳雯 刘强 严涛 孟晶 |
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| 作者单位： | 徐州医学院麻醉学院;徐州医学院麻醉药理学教研室; |
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| 基金项目： | 江苏省高校自然科学基础研究项目(08KJD320006) |
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| 摘 要： | 目的对小鼠避暗实验三种常用训练方法的效果进行比较.方法小鼠腹腔注射氯胺酮(25mg.kg-1)建立遗忘模型,分别采用单次适应单次电击(MOS)法,单次适应限时训练(MOL)法,多次适应限时训练(MUL)法训练小鼠并于24h后进行测试,记录步入潜伏期和错误次数.结果与对照组相比,MOS法仅显示步入潜伏期的差异(P＜ 0....
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| 关 键 词： | 避暗实验 小鼠 训练方法 氯胺酮 |
EFFECT COMPARISON OF THREE KINDS OF STEP TRROUGH TEST'S TRAINING METHODS IN MICE |
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| LIAO Yi-cong,LI-Yan,WANG Lei,WANG Ya-xiang,ZHAO Bing-xue,DENG Qian,TAN Yan-wen,LIU Qiang,YAN Tao,MENG Jing.EFFECT COMPARISON OF THREE KINDS OF STEP TRROUGH TEST'S TRAINING METHODS IN MICE[J].Journal of Jinggangshan University(Natural Sciences Edition),2011(4):101-103. |
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| Authors: | LIAO Yi-cong LI-Yan WANG Lei WANG Ya-xiang ZHAO Bing-xue DENG Qian TAN Yan-wen LIU Qiang YAN Tao MENG Jing |
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| Institution: | LIAO Yi-cong1,LI-Yan1,WANG Lei1,WANG Ya-xiang1,ZHAO Bing-xue1,DENG Qian1,TAN Yan-wen1,LIU Qiang1,YAN Tao1,*MENG Jing2(1.Institute of Anesthesiology,Xuzhou Medical College,Xuzhou,Jiangsu 221002,China,2.Department of Anesthetic Pharmacology,China) |
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| Abstract: | Objective：To compare the effects of three kinds of step through test＇s training methods in mice.Methods：Amnestic model was established by intraperitoneal injection of ketamine（25 mg·kg-1）.The mice were trained by mono-adaptation and mono-shock（MOS） method,mono-adaptation and time-limited（MOL） method or multi-adaptation and time-limited（MUL） method,then the step through latency and error times were observed in the testing trial 24 h later.Results：Compared with the control group,the step through latency just indicated difference in MOS method（P 0.05）;both kinds of indication showed significant difference in MOL and MUL methods,the indexes in latter one were more significant（P 0.01）.Conclusion：Multi-adaptation and time-limited method was testified to be relatively dependable for step through test in mice. |
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| Keywords: | step through test mice training method ketamine |
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