中等强度体力活动与T2DM风险——系统综述

目的系统评价中等强度体力活动与T2DM之间的关系。方法检索EMBASE和Medline(截止2010年7月)相关文献,并追踪参考文献目录。剔除未将中等强度体力活动与剧烈活动(>6MET)区分开的文献。采用随机效应模型计算总相对风险(RR)。结果对10个队列研究进行分析,共有301,221名参与者,其中9,367例发病。其中5例专门研究了步行的作用。参与规律的中等强度体力活动与静坐少动者相比,T2DM的总RR为0.69(95%CI0.58～0.83)。同样,规律步行(尤其是快走≥2.5h/周)与基本不步行者相比RR为0.70(95%CI0.58～0.84)。调整了BMI后相关性仍旧有显著性。在美国和欧洲,男性与女性中都观察到类似的相关性。结论 MPA可使T2DM发病风险降低约30%,其相关性部分独立于BMI,提示MPA降低T2DM风险的作用也可发生在未出现体重下降的人群。快走被认为是预防糖尿病的最佳手段,但步行的最佳持续时间和速度及最佳组合方式还需进一步研究。预防T2DM要加大力度宣传MPA的益处,鼓励更多的人参与进来。

PHYSICAL ACTIVITY OF MODERATE INTENSITY AND RISK OF TYPE 2 DIABETES MELLITUS

Objective:To systematically evaluate the correlation between physical activity of moderate intensity and risk of type 2 diabetes mellitus(T2DM).Methods:Relative references were searched in EMBASE and Medline(end at July 2010) and their reference lists were tracked.The studies that did not assess physical activity of moderate intensity independent of activities of vigorous intensity(>6METs) were excluded.General relative risks(RRs) was calculated using a random-effects model.Results:We identified 10 prospect...