A possible method for improving the efficacy of dapsone |
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| Authors: | K Prabhakaran EB Harris WF Kirchheimer |
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| Institution: | (1) U.S. Public Health Service Hospital, 70721 Carville, LA, USA |
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| Abstract: | Summary The antileprosy drug dapsone is unable to penetrate intactMycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity. |
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