HLA-B*6701 as a subtype performing post-selected marking gene for cervical cancer |
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| Authors: | Xiaoping Qiu Ning Tao Yun Tan Xinxing Wu |
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| Institution: | (1) Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc. NCI-Frederick, Frederick, MD, 21702, USA;(2) Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA;(3) Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA;(4) Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02114, USA;(5) Present address: Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; |
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| Abstract: | A method of sequence-based typing (SBT) has been adopted to assort types of exons 2 and 3, which have the most polymorphism,
of HLA-B locus of the Tujia nation group in Hubei province. The correlation among the HLA-B alleles, human papillomavirus
(HPV) infection and cervical cancer risk has also been investigated. Under the condition of resident location and age, race
unified, 100 specimens of cancer patients were sampled as a case group, of which 86 were HPV positive and were screened for
HLA-B alleles; while 187 specimens were taken from healthy people, of which 92 were HPV negative as a control group. The result
shows that by comparing the above mentioned 86 HPV positive cervical cancer group and 92 HPV negative normal group, it was
concluded that HLA-B*6701 was only found in the cervical cancer group (p < 0.034), which shows that HLA-B*6701 can be used as an important candidate biological marking gene for generation of cervical
cancer in Wufeng county of Hubei province. |
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