Cell-based biosensors: Towards the development of cellular monitoring |
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Authors: | Gaixia Xu Yicong Wu Rong Li Ping Wang Weiming Yan Xiaoxiang Zheng |
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Affiliation: | (1) Biosensor National Special Laboratory, Key Laboratory of BME of the Ministry of Education, Department of Biomedical Engineering, Zhejiang University, 310027 Hangzhou, China |
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Abstract: | Cell-based biosensors (CBBs), a research hotspot of biosensors, which treat living cells as sensing elements, can detect the functional information of biologically active analytes. They characterize with high sensitivity, excellent selectivity and rapid response, and have been applied in many fields, such as biomedicine, environmental monitoring and pharmaceutical screening. Recently cell-cultured technology, silicon microfabrication technology and genetic technology have promoted exploration of CBBs dramatically. To elucidate the novel research findings and applications of cell-based biosensors, this paper summarizes various research approaches, presents some challenges and proposes the research trends. |
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Keywords: | cell-based biosensors functional analysis cellular microenvironment electrophysiological genetically-engineered |
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