| 7β-[2-(2-氨噻唑-4-基)-(Z)-2-甲氧亚胺乙酰氨基]-3-(2-芳基-1,3,4-恶二唑-5-硫亚甲基)头孢菌素衍生物抑菌活性及构效关系探讨 |
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| 引用本文： | 王勤,赵祁,王书芳,何永刚,惠新平,张自义. 7β-[2-(2-氨噻唑-4-基)-(Z)-2-甲氧亚胺乙酰氨基]-3-(2-芳基-1,3,4-恶二唑-5-硫亚甲基)头孢菌素衍生物抑菌活性及构效关系探讨[J]. 兰州大学学报(自然科学版), 2003, 39(1): 77-79 |
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| 作者姓名： | 王勤 赵祁 王书芳 何永刚 惠新平 张自义 |
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| 作者单位： | 1. 兰州大学生命科学学院,甘肃,兰州,730000
2. 兰州大学化学化工学院,甘肃,兰州,730000 |
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| 基金项目： | 甘肃省科技攻关资助项目 ( GS0 2 2 -A4 3-1 36) . |
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| 摘 要： | 采用2倍浓度稀释法、平板抑菌实验法、比浊法检测了衍生物对金黄色葡萄球菌等的最小抑菌浓度(MIC)及时效、量效关系，比较了6种衍生物不同的抑菌作用。结果表明，该系列头孢菌素衍生物对实验菌株均有明显的抑制活性。对金葡菌最为敏感，其中7β[2—(2—氨噻唑—4—基)—(Z)—2—甲氧亚肢乙酰氨基]—3—(2—芳基—1，3，4—恶二唑5—硫亚甲基)头孢—3—烯—4—羧酸a作用最强，与头孢拉定相似。提示该类衍生物是一类对受试菌株中金葡菌最为敏感的化合物。
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| 关 键 词： | 抗生素 头抱菌素 抑菌活性 构效关系 金黄色葡萄球菌 最小抑菌浓度 细菌生长曲线 |
| 文章编号： | 0455-2059(2003)01-0077-03 |
| 修稿时间： | 2002-01-18 |
Antibacterial effect and structure-activity relationship of cephalosporin derivatives |
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| WANG Qin,ZHAO Qi,WANG Shu-fang,HE Yong-gang,HUI Xin-ping,ZHANG Zi-yi. Antibacterial effect and structure-activity relationship of cephalosporin derivatives[J]. Journal of Lanzhou University(Natural Science), 2003, 39(1): 77-79 |
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| Authors: | WANG Qin ZHAO Qi WANG Shu-fang HE Yong-gang HUI Xin-ping ZHANG Zi-yi |
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| Affiliation: | WANG Qin1,ZHAO Qi1,WANG Shu-fang1,HE Yong-gang1,HUI Xin-ping2,ZHANG Zi-yi2 |
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| Abstract: | The aim of the paper was to study the antibacterial effect and structural activity relationship of cephalosporin derivatives. Double dilution method was used to compare the different concentrations and the cup-plate technique and nephelometery were used to investigate the growth-curves of S.aureus and E.coli. The cephalosporin derivatives showed obvious antibacterial activity, especially to S.aureus, and derivative a is the best activity. The results showed that this kind of derivatives was sensitive to S.aureus. |
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| Keywords: | cephalosporin antibacterial activity growth curve Stapyhyoccus aureus |
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