The pleiotropic functions of aspirin: mechanisms of action |
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| Authors: | A R Amin M G Attur M Pillinger S B Abramson |
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| Institution: | (1) Department of Rheumatology, Room 1600, Hospital for Joint Diseases, 301 E. 17th St., New York (New York 10003, USA), Fax +212 598 7604, US;(2) Department of Medicine, New York University Medical Center, New York (New York, USA), US;(3) Department of Pathology, Kaplan Cancer Center, New York University Medical Center, New York (New York, USA), US |
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| Abstract: | Recent studies have suggested that aspirin and aspirin-like compounds have a variety of actions in addition to their well-studied
ability to inhibit cyclooxygenases. These actions include inhibition of the uncoupling of oxidative phosphorylation, decreases
in adenosine triphosphate stores, increases in extracellular adenosine, downregulation of the expression and activity of inducible
nitric oxide synthetase, inhibition and/or stimulation of various mitogen-activated protein kinase activities and inhibition
of nuclear factor binding κB site (NF-κB) activation. Moreover, aspirin-like compounds have recently been shown to have previously
unappreciated clinical and biological effects, some apparently independent of cyclooxygenase. In this review we discuss the
various mechanisms of action of aspirin-like compounds and their relevance to clinical disease and therapy.
Received 1 February 1999; received after revision 1 April 1999; accepted 7 May 1999 |
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| Keywords: | , Aspirin, prostaglandin, COX, signal transduction, NF-κ,B, NOS, |
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