Pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats |
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| Authors: | L J Forman W E Sonntag V W Hylka J Meites |
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| Institution: | (1) School of Osteopathic Medicine, Department of Medicine, University of Medicine and Dentistry of New Jersey, 08103 Camden, New Jersey, USA;(2) Present address: Neuroendocrine Research Laboratory, Department of Physiology, Michigan State University, 48824 East Lansing, MI |
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| Abstract: | Summary Pituitary content and concentration of growth hormone was significantly reduced, and hypothalamic somatostatin content significantly increased, in old constant estrous as compared to young female rats. Increased levels of somatostatin may contribute to the decrease in pituitary growth hormone levels in these animals.This work was supported by NIH Research grants AG-00416 (J.M.) from the National Institute on Aging, AM-04784 (J.M.) from the NIAMDD, and NIA postdoctoral fellowships AG-05208 (L.J.F.) and AG-05147 (W.E.S.). |
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| Keywords: | Aging growth hormone somatostatin |
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