| 非嵌插类药物与DNA作用的分子机制 |
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| 引用本文： | 戴亚,金闻博. 非嵌插类药物与DNA作用的分子机制[J]. 合肥工业大学学报(自然科学版), 1993, 0(4) |
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| 作者姓名： | 戴亚 金闻博 |
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| 作者单位： | 合肥经济技术学院(戴亚)，合肥经济技术学院(金闻博) |
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| 摘 要： | 本文概述了非嵌插类药物与DNA作用的分子机制,考察了DNA螺旋小沟结合药物的碱基序列特异性,药物-DNA相互作用的性质和相互作用能,以及研究药物与DNA作用分子机制的意义。
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| 关 键 词： | 药物 DNA 小沟结合 分子机制 |
THE MOLECULAR ORIGIN OF NON-INSERTED DRUG-DNA REACTION |
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| Dai Ya Jin Wenbo. THE MOLECULAR ORIGIN OF NON-INSERTED DRUG-DNA REACTION[J]. Journal of Hefei University of Technology(Natural Science), 1993, 0(4) |
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| Authors: | Dai Ya Jin Wenbo |
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| Abstract: | In this paper,the molecular origin of non-inserted drug-DNA reaction was revid-wed ; Some related aspects were studied and a few helpful consequences were obtained. These aspects are the speciality of DNA base sequence in the process of minorgroove combination with drugs, the nature and the interaction energy of drug-DNA interaction and the significance of tesearch into the molecular origin of drug-DNA interaction. |
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| Keywords: | Drug DNA Minorgroove Combination (bind within the minor groove ) Molecular origin |
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