反溶剂重结晶法制备硫酸沙丁胺醇颗粒

实验采用反溶剂重结晶法对硫酸沙丁胺醇进行超细化。将乙醇、异丙醇、丙酮作为反溶剂进行了对比实验，最后选定丙酮作为该体系的反溶剂，并且确定了最佳反溶剂和溶液的体积比为10∶1。结果证明，体系的过饱和度ΔC越大重结晶所得到的颗粒就越小，采用反加法、低温、高搅拌速度能够增大体系的过饱和度，得到 300nm的针状颗粒产品。

Preparation of ultrafine particlesof salbutamol sulfate by anti-solvent precipitation

Ultrafine particles of salbutamol sulfate were produced by anti-solvent precipitation. The optimal ratio of volume of anti-solvent to salbutamol sulfate solution was 10∶1, in which acetone was selected as the anti-solvent. The experimental results showed that the particle size became smaller with the increasing of the supersaturation (ΔC)of the solution, so the ultrafine particles of salbutamol sulfate of 300nm can be produced by adding the solution to the anti-solvent, especially in a high stirring speed and a low crystallization temperature.