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| SH2D7基因及其编码蛋白的生物信息学分析 | |
| 引用本文： | 杨华,杨风琴,廖国玲,刘学英.SH2D7基因及其编码蛋白的生物信息学分析[J].科技导报(北京),2015,33(2):35-38. |
| 作者姓名： | 杨华 杨风琴 廖国玲 刘学英 |
| 作者单位： | 1. 宁夏医科大学检验学院, 银川750004; 2. 宁夏检验医学研究所, 银川750004 |
| 基金项目： | 宁夏自然科学基金项目(NZ11135) |
| 摘 要： | 为了对SH2D7 基因序列及其编码蛋白进行生物信息学分析,应用NCBI 数据库和ExPASy 等程序,对SH2D7 基因核苷酸序列进行了分析,并预测了其编码蛋白的理化性质及二级结构等。结果表明,SH2D7 基因定位于人类染色体15q25.1,包含了6 个外显子和5 个内含子。SH2D7 基因编码蛋白的功能主要涉及基因表达调控、信号传导等;分子量约为49.8 kD,等电点为5.99,是一种亲水蛋白,主要位于细胞核中,有35 个磷酸化位点及22 个抗原位点。 |
| 关 键 词： | 肿瘤 SH2D7 生物信息学分析 |
| 收稿时间： | 2014-07-07 |
Bioinformatic analysis of SH2D7 and its encoded protein |
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| YANG Hua;YANG Fengqin;LIAO Guoling;LIU Xueying.Bioinformatic analysis of SH2D7 and its encoded protein[J].Science & Technology Review,2015,33(2):35-38. | |
| Authors: | YANG Hua;YANG Fengqin;LIAO Guoling;LIU Xueying |
| Institution: | 1. School of Laboratory Medicine, Ningxia Medical University, Yinchuan 750004, China; 2. Ningxia Institute of Laboratory Medicine, Yinchuan 750004, China |
| Abstract: | The bioinformatic software is used to predict the nucleotide sequence of SH2D7 and the second structure of its encoding protein. It is shown that SH2D7 is located on the human chromosome 15q25.1, containing six exons and five introns. SH2D7 protein is mainly involved in the regulation of the gene expression and the signal transduction. Its molecular weight is 49.8 kD and the isoelectric point is 5.99. SH2D7 is a hydrophilic protein mainly located in the nucleus and there are 35 phosphorylation sites and 22 epitopes bit in the SH2D7 protein sequence. |
| Keywords: | cancer SH2D7 bioinformatic analysis |
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