Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans |
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| Authors: | M Martinelli R Winterhalder P Cerretelli H Howald H Hoppeler |
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| Affiliation: | Department of Anatomy University of Bern, Switzerland. |
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| Abstract: | Muscle ultrastructural changes during a typical expedition to the Himalayas were analyzed by taking muscle biopsies from seven climbers before and after their sojourn at high altitude (over 5000 m for 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A quantitative evaluation was made of lipofuscin, satellite cells and myonuclei. Significant increases of the volume densities of lipofuscin (+ 235%) and satellite cells (+ 215%) were observed. |
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