| 绿茶多酚表没食子儿茶素没食子酸酯对肝癌Hep G2细胞的增殖抑制作用和凋亡诱导效应 |
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| 引用本文： | 王坤英,梁清清,李卫国,王辉.绿茶多酚表没食子儿茶素没食子酸酯对肝癌Hep G2细胞的增殖抑制作用和凋亡诱导效应[J].河南师范大学学报(自然科学版),2009,37(1). |
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| 作者姓名： | 王坤英 梁清清 李卫国 王辉 |
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| 作者单位： | 1. 河南师范大学,生命科学学院,河南,新乡,453007
2. 新乡医学院,免疫学研究中心,河南,新乡,453003 |
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| 基金项目： | 河南省教育厅自然科学基金，河南省动物学重点学科基金 |
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| 摘 要： | 表没食子儿茶素-3-没食子酸酯((-)-epigallocatechin-3-gallate,EGCG)是绿茶多酚的主要成分,具有抗氧化、抗衰老、抗过敏和潜在的抗癌特性.本文运用MTT试验,DAPI染色和Annexin V-FITC分析了EGCG对肝癌Hep G2细胞的增殖抑制作用和凋亡诱导.结果表明,EGCG对Hep G2细胞具有明显的增殖抑制作用,存在剂量和时间依赖效应;EGCG能诱导Hep G2细胞凋亡,并具有剂量依赖效应.
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| 关 键 词： | Hep G2细胞 表没食子儿茶素-3-没食子酸酯(EGCG) 细胞增殖 细胞凋亡 |
A Green Tea Polyphenol,Epigalocatechin-3-gallate,Inhibits Proliferation and Induces Apoptosis in Hep G2 Cells |
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| WANG Kun-ying,LIANG Qing-qing,LI Wei-guo,WANG Hui.A Green Tea Polyphenol,Epigalocatechin-3-gallate,Inhibits Proliferation and Induces Apoptosis in Hep G2 Cells[J].Journal of Henan Normal University(Natural Science),2009,37(1). |
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| Authors: | WANG Kun-ying LIANG Qing-qing LI Wei-guo WANG Hui |
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| Institution: | 1.College of Life Sciences;Henan Normal University;Xinxiang 453007;China;2.Center of Immunology;Xinxiang Medical University;Xinxiang 453003;China |
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| Abstract: | Epigallocatechin-3-gallate(EGCG)is the major bioactive polyphenol present in green tea.It possesses antioxidant,anti-senescence,anti-inflammatory,and potential anti-carcer activity.In this paper,cell proliferation inhibition of EGCG on human hepatocellular carcinoma,Hep G2 cell line,has been studied with MTT assay,and apoptotic induction of EGCG on Hep G2 cells is measured by DAPI staining and Annexin V-FITC.The results show that EGCG inhibits proliferation of Hep G2 cells with dose-and time-dependence,and ... |
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| Keywords: | Hep G2 cell (-)-epigallocatechin-3-gallate(EGCG) cell proliferation cell apoptosis |
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