The involvement of porphyrogenic steroids in the development of experimental porphyria |
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| Authors: | V Graef S W Golf G Goerz |
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| Institution: | (1) Institut für Klinische Chemie und Pathogiochemie der Universität Giessen, Friedrichstrasse 24, D-6300 Giessen, (Federal Republic of Germany);(2) Universitäts-Hautklinik Düsseldorf, Moorenstrasse 5, D-4000 Düsseldorf 1, (Federal Republic of Germany) |
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| Abstract: | Summary Hexachlorobenzene alters the hepatic steroid metabolism, and it was suggested that a porphyria was induced by overproduction of 5 -H-steroids. Structurally similar chlorinated hydrocarbons (pentachlorobenzene, pentachlorophenol, 2,4,5-trichlorophenol) without porphyrogenic activity did not affect the steroid metabolism in rat liver.Dedicated to Prof. Dr. L. Róka on the occasion of his 60th birthday. |
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