| 小鼠大脑皮层中ADAM17表达的降低对神经元前体细胞外向迁移的抑制作用 |
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| 引用本文： | 潘乐,马执行,李擎瑜,刘彬,盖敏,郑煜芳.小鼠大脑皮层中ADAM17表达的降低对神经元前体细胞外向迁移的抑制作用[J].复旦学报(自然科学版),2011(5):597-604,F0002;F0003. |
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| 作者姓名： | 潘乐 马执行 李擎瑜 刘彬 盖敏 郑煜芳 |
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| 作者单位： | 复旦大学生命科学学院生理学和生物物理学系; |
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| 基金项目： | 国家自然科学基金资助项目(30800322); 上海市浦江人才计划资助项目(08PJ1401300); 复旦大学脑研究院开放课题资助项目 |
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| 摘 要： | 在发育过程中神经元前体细胞的外向迁移对于大脑皮层的多层结构建立有着重要作用.金属蛋白酶家族的成员ADAM17（A Disintegrin And Metalloprotease 17）对于多种膜蛋白的成熟释放有着重要作用,包括多个表皮生长因子受体的配体以及Notch等蛋白.这些底物中有多个对神经干细胞的增殖、分化、迁移...
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| 关 键 词： | ADAM17 大脑皮层发育 神经元前体细胞 神经元外向迁移 肿瘤坏死因子α-转化酶 |
Down-Regulation of ADAM17 Expression in Mouse Developing Cortex Causes Neuron Migration Defect |
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| PAN Le,MA Zhi-xing,LI Qing-yu,LIU Bin,GAI Min,ZHENG Yu-fang.Down-Regulation of ADAM17 Expression in Mouse Developing Cortex Causes Neuron Migration Defect[J].Journal of Fudan University(Natural Science),2011(5):597-604,F0002;F0003. |
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| Authors: | PAN Le MA Zhi-xing LI Qing-yu LIU Bin GAI Min ZHENG Yu-fang |
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| Institution: | PAN Le,MA Zhi-xing,LI Qing-yu,LIU Bin,GAI Min,ZHENG Yu-fang(Department of Physiology and Biophysics,School of Life Sciences,Fudan University,Shanghai 200433,China) |
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| Abstract: | The migration of neuronal progenitor cells towards out layer is crucial for the multiple-layer formation of mammalian cortex during development.ADAM17(a disintegrin and metalloprotease 17) is a metalloprotease that can shed many membrane proteins including Notch and ligands of EGFR,which have important function during neural stem cells proliferation,migration,and differentiation.To explore the function of ADAM17 in cortex development,RNA interference and IUE(in utero electropration) was used to knock down t... |
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| Keywords: | ADAM17 cortex development neuronal progenitor cells neuron migration TACE |
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