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| 手性诱导试剂(S)-(+)-2-苯胺甲基吡咯烷的合成 | |
| 引用本文： | 黄新苹,刘远方,杨冉,屈凌波. 手性诱导试剂(S)-(+)-2-苯胺甲基吡咯烷的合成[J]. 江西师范大学学报(自然科学版), 2011, 35(4): 347-349 |
| 作者姓名： | 黄新苹 刘远方 杨冉 屈凌波 |
| 作者单位： | 1. 郑州师范学院化学系,河南郑州,450044 2. 郑州大学化学系,河南郑州,450052 3. 郑州大学化学系,河南郑州 450052;河南工业大学,河南郑州 450001 |
| 基金项目： | 河南省科技攻关重点项目(112102310298); 河南省教育厅自然科学基础研究计划(2010C150007)资助项目 |
| 摘 要： | 采用新的合成路线,以L-谷氨酸为原料,通过内酰胺环化、离子交换树脂分离、苯胺酰胺化、AlLiH4还原等一系列反应,合成手性诱导试剂(S)-(+)-2-苯胺甲基吡咯烷,经元素分析、质谱和核磁共振谱等对产物的结构进行了确证.该反应具有条件温和、后处理操作简单、产率较高等优点. |
| 关 键 词： | L-谷氨酸 手性试剂 (S)-2-苯胺甲酰基吡咯烷-5-酮 (S)-(+)-2-苯胺甲基吡咯烷 |
The Synthesized for Chiral Agent (S)-2-(Anilinomethyl)Pyrrolidine |
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| HUANG Xin-ping,LIU Yuan-fang,YANG Ran,QU Ling-bo. The Synthesized for Chiral Agent (S)-2-(Anilinomethyl)Pyrrolidine[J]. Journal of Jiangxi Normal University (Natural Sciences Edition), 2011, 35(4): 347-349 | |
| Authors: | HUANG Xin-ping LIU Yuan-fang YANG Ran QU Ling-bo |
| Affiliation: | HUANG Xin-ping1,LIU Yuan-fang1,YANG Ran2,QU Ling-bo2,3(1.Department of Chemistry,Zhengzhou Normal University,Zhengzhou Henan 450044,China,2.Department of Chemistry,Zhengzhou University,Zhengzhou Henan 450052,3.Henan University of Technology,Zhengzhou Henan 450001,China) |
| Abstract: | (S)-2-(anilinomethyl)pyrrolidine was effectively synthesized from L-glumatic acid via pyrroglumatic acid through lactam cyclization,separation by ion-exchange chromatography,aniline amidation,AlLiH4 deoxidiza-tion reactions.The target products were characterized by elemental analysis,MS,and 1H NMR.This new method possesses such advantages as the mild reaction conditions,simple operation and high yield. |
| Keywords: | L-glutamic acid chiral reagent (S)-5-oxo-N-phenylpyrrolidine-2-carboxamide (S)-( )-2-(anilinome-thyl)pyrrolidine |
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