| Role of FGF-2／FGFR signaling pathway in cancer and its signification in breast cancer |
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| 作者姓名： | FANGJianwu HUANGSiluo LIUHuisheng M.Crepin XUTao LIUJianfeng |
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| 作者单位： | [1]InstituteofBiophyscis＆BiochemistryofHuazhongUniversityofScience＆Technology,Wuhan430074,China [2]CNRS-UPR9023MecanismesMoleculairesdesCommunicationsCellulairesCCIPE,34090,France [3]LaboratoiredeRechercheOncologieMoleAculaireHumaine（EA445）,UFRLeAonarddeVinci,UniversiteAParis-nord,74,rueMarcelCachin,93012,Bobigny,France |
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| 摘 要： | Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor抯 intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer.
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| 关 键 词： | 乳腺癌 蛋白质 肝磷脂 硫酸乙酰肝素 血管生成 |
| 收稿时间： | 2003-04-22 |
Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer |
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| FANGJianwu HUANGSiluo LIUHuisheng M.Crepin XUTao LIUJianfeng.Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer[J].Chinese Science Bulletin,2003,48(15):1539-1547. |
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| Authors: | Jianwu?Fang Siluo?Huang Huisheng?Liu M?Crepin Tao?Xu Email author" target="_blank">Jianfeng?LiuEmail author |
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| Institution: | 1.Institute of Biophyscis & Biochemistry of Huazhong University of Science & Technology,Wuhan,China;2.CNRS-UPR 9023 Mecanismes Moleculaires des Communications CellulairesCCIPE,France;3.Laboratoire de Recherche Oncologie Mole?culaire Humaine (EA 445), UFR Le?onard de Vinci,Universite? Paris-nord,Bobigny,France |
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| Abstract: | Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer. |
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| Keywords: | FGF-2 MCF-7 breast cancer signaling pathway tumor |
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