| Mab HIM70对人Np NADPH氧化酶的调节（Ⅱ） |
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| 引用本文： | 法祥光,杨琳.Mab HIM70对人Np NADPH氧化酶的调节（Ⅱ）[J].科学技术与工程,2002,2(3):34-37. |
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| 作者姓名： | 法祥光 杨琳 |
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| 作者单位： | 中国医学科学院,中国协和医科大学血液学研究所,天津,300020 |
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| 基金项目： | 国家自然科学基金(39970188) |
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| 摘 要： | 在发现Mab HIM70对Np NADPH氧化酶胸浆组分p47^phox、p67^phox和Rac2的表达和参与NADPH氧化酶活化均有降调节作用基础上，进一步探索了Mab HIM70对该降调节作用的机理。发现Mab HIM70可能对NADPH氧化酶上游PKC、PTK及PI3K信号传递途径的活化水平有降调节作用，该单抗对NADPH氧化酶活化有降调节的作用可能与此有关。
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| 关 键 词： | Mab HIM70 调节 人体细胞 NADPH氧化酶 p47^phox p67^phox Rac2 中性粒细胞 激酶抑制剂 降调节作用 |
| 修稿时间： | 2002年1月15日 |
The Regulation of NADPH Oxidase in Human Np by Mab HIM_(70) |
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| FA Xiangguang YANG Lin.The Regulation of NADPH Oxidase in Human Np by Mab HIM_(70)[J].Science Technology and Engineering,2002,2(3):34-37. |
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| Authors: | FA Xiangguang YANG Lin |
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| Abstract: | It was found that the expressiones of p47~(phox),p67~(phox), Rac2 and the activation of NADPH oxidase were down-regulated obviously by Mab HIM_(70),and further,was explored the mechnism how Mab HIM_(70) influence the activation of NADPH oxidase in human Np. The results shown the down-regulation effect of Mab HIM_(70) on NADPH oxidase may related with activities of PKC,PTK and PI3K pathways were reduced by McAb HIM_(70). |
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| Keywords: | NADPH oxidase p47~(phox) p67~(phox) Rac2 Neutrophil |
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