The pathogenic role of interleukin-27 in autoimmune diabetes |
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Authors: | R Wang G Han J Wang G Chen R Xu L Wang X Li B Shen Y Li |
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Institution: | (1) Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road, No. 27, Beijing, 100850, China;(2) Institute of Immunology, Medical School of Henan University, Kaifeng, China |
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Abstract: | Interleukin (IL)-27 is an IL-12-related cytokine that can promote both anti- and pro-inflammatory immune responses. This study
investigated the potential role of IL-27 in autoimmune diabetes. We detected a high level of IL-27 in diabetic NOD mice. In
addition, blockade of IL-27 significantly delayed the onset of diabetic splenocyte-transferred diabetes, while IL-27-treated
diabetic splenocytes promoted the onset of the disease, compared with untreated controls. Furthermore, IL-27 up-regulated
pro-inflammatory cytokines IFN-γ and IL-17 and down-regulated anti-inflammatory cytokines IL-4, TGF-β, and IL-10 secreted
by diabetic splenocytes. These results demonstrate a pathogenic role of IL-27 in T cell-mediated autoimmune diabetes.
Received 02 September 2008; received after revision 27 September 2008; accepted 01 October 2008
R. Wang, G. Han: These authors contributed equally to this work. |
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Keywords: | " target="_blank"> IL-27 autoimmune diabetes IFN-γ IL-17 IL-4 TGF-β IL-10 |
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