| A study on in vitro and in vivo bioactivity of nano hydroxyapatite/polymer biocomposite |
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| 引用本文： | YANG Kong WEI Jie WANG ChaoYuan LI YuBao. A study on in vitro and in vivo bioactivity of nano hydroxyapatite/polymer biocomposite[J]. 科学通报(英文版), 2007, 52(2): 267-271. DOI: 10.1007/s11434-007-0035-1 |
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| 作者姓名： | YANG Kong WEI Jie WANG ChaoYuan LI YuBao |
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| 作者单位： | [1]School of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China [2]School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China [3]College of Life Science, South Central University for Nationalities, Wuhan 430074, China [4]Analytical and Testing Center, Sichuan University, Chengdu 610064, China |
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| 基金项目： | Supported by the Ministry of Science and Technology of China and the Ministry of Education of China. |
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| 摘 要： | When bioactive materials are implanted in vivo, a bone-like apatite layer can be found on their surfaces, which is critical to the establishment of bone-bonding between materials and living tissues. In this study, bone-like apatite formation in vitro and in vivo on surface of nano apatite/polyamide (n-HA/PA66) composite was investigated, and the interface between the implanted composite and surrounding bone tissue of rabbit were also examined. The results revealed that in both simulated body fluids (SBF) and dorsal muscles of rabbit, bone-like apatite could form on the biocomposite surface. When the samples were implanted in cortical bone, they combined directly with the natural bone without fibrous tissue in-between. The results showed that the n-HA/PA66 biocomposite had excellent bioactivity, which might be a good candidate for bone defect replacement.
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| 关 键 词： | 生物复合材料 生物活性 磷灰石 活组织 生物医学 |
| 收稿时间： | 2006-03-27 |
| 修稿时间： | 2006-03-272006-04-24 |
A study on in vitro and in vivo bioactivity of nano hydroxyapatite/polymer biocomposite |
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| Yang Kong,Wei Jie,Wang ChaoYuan,Li YuBao. A study on in vitro and in vivo bioactivity of nano hydroxyapatite/polymer biocomposite[J]. Chinese science bulletin, 2007, 52(2): 267-271. DOI: 10.1007/s11434-007-0035-1 |
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| Authors: | Yang Kong Wei Jie Wang ChaoYuan Li YuBao |
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| Affiliation: | (1) School of Life Science and Technology, Southwest University for Nationalities, Chengdu, 610041, China;(2) School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China;(3) College of Life Science, South Central University for Nationalities, Wuhan, 430074, China;(4) Analytical and Testing Center, Sichuan University, Chengdu, 610064, China |
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| Abstract: | When bioactive materials are implanted in vivo, a bone-like apatite layer can be found on their surfaces, which is critical to the establishment of bone-bonding between materials and living tissues. In this study, bone-like apatite formation in vitro and in vivo on surface of nano apatite/polyamide (n-HA/PA66) composite was investigated, and the interface between the implanted composite and surrounding bone tissue of rabbit were also examined. The results revealed that in both simulated body fluids (SBF) and dorsal muscles of rabbit, bone-like apatite could form on the biocomposite surface. When the samples were implanted in cortical bone, they combined directly with the natural bone without fibrous tissue in-between. The results showed that the n-HA/PA66 biocomposite had excellent bioactivity, which might be a good candidate for bone defect replacement. |
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| Keywords: | nano biocomposite bone-like apatite bioactivity |
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