Drug uptake by lung slices from paraquat-pretreated rats

Summary Lung slices from male Sprague-Dawley rats pretreated with paraquat (PQ) (100 moles·kg^–1, i.v.) 16 h before sacrifice, accumulated less PQ in vitro than lung slices from saline-treated controls. Neither lung slices from PQ-pretreated nor saline control animals released (effluxed) PQ accumulated in vitro. The accumulation and efflux of imipramine and 5-hydroxytryptamine by lung slices was unaffected by prior in vivo administration of PQ.