A novel theoretical model for mass transfer of hollow fiber hemodialyzers

Hemodialyzers have been applied to hemodialysiswidely. In order to get accurate mass transfer coefficient and clearance to determine treatment time, their masstransfer models have been studied deeply. The domesticstudy on hemodialyzers is later, focuses on experiment, and seldom refers to theoretical mechanism1,2], but theoverseas research is more in-depth. Simple one-dimensional models have been used to simulate mass transfer in hemodialyzers by many re-searchers3—7]. Their models assumed …

A novel theoretical model for mass transfer of hollow fiber hemodialyzers

A novel theoretical model for mass transfer of hollow fiber bundles in hemodialyzers is presented. In the model, a hemodialyzer is considered as a porous zone which is composed of two non-interpenetrating porous flow zones. Firstly, the dialysate side (shell side) is thought as a porous medium zone. Then by solidifying the dialysate flow zone and the occupied zone by hollow fiber membrane, the rest zone of hemodialyzer (i.e. blood side or lumen side) is con-sidered as a porous medium zone too. Finally, the interface of the two flow zones is the fiber membrane through which mass transfer is performed. The dialysate and blood flows are all described by Navier-Stokes equations with Darcy momentum source terms. Kedem-Katchalsky equations as other source terms are added into Navier-Stokes equations to simulate the permeating flux through the membrane. All equations must be coupled together in the process of com-puting. The model is validated by the experimental data in literature. The simulative results show that the predicted clearances agree well with the experimental data, and the model in this paper is better than other models for the fore-cast of clearance.