| 几种不同高分子生物材料吸附FG与单克隆抗体M1结合亲合力的研究 |
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| 引用本文： | 万昌秀,李天全.几种不同高分子生物材料吸附FG与单克隆抗体M1结合亲合力的研究[J].四川大学学报(自然科学版),1999(2). |
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| 作者姓名： | 万昌秀 李天全 |
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| 作者单位： | 四川大学应用高材系(万昌秀)，四川大学化学系(李天全) |
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| 摘 要： | 利用鼠抗人血纤维蛋白原（Ｆｉｂｒｉｎｏｇｅｎ，ＦＧ）单克隆抗体Ｍ１作为血小板替代物，以酶联免疫吸附测定（ＥｎｚｙｍｅＬｉｎｋｅｄｌｍｍｕｓｏｒｂｅｎｔＡｓｓａｙ，ＥＬＩＳＡ）为手段，通过ＦＧ－Ｍ１复合物结合亲合力常数ｋａ的测定，对几种高聚物材料血液相容性进行了评价．测定了不同材料表面的ＸＰＳ谱，比较了不同组成的材料表面血液相容性的差异
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| 关 键 词： | 单克隆抗体 蛋白吸附 结合亲合力 |
FIBRINOGEN ADSORBED TO DIFFERENT POLYMER BIOMATERIALS AND STUDYING ON MONOCLONAL ANTIBODY M1 BINDING AFFINITY |
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| WAN Chang xiu,LI Tian quan.FIBRINOGEN ADSORBED TO DIFFERENT POLYMER BIOMATERIALS AND STUDYING ON MONOCLONAL ANTIBODY M1 BINDING AFFINITY[J].Journal of Sichuan University (Natural Science Edition),1999(2). |
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| Authors: | WAN Chang xiu LI Tian quan |
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| Abstract: | Using monoclonal antibody M1 as a substitute of the platelet the binding affinity of FG M1 complex of a few polymer biomaterials was measured by ELISA.Compared the changs in binding affinity of M1 to one of the platelet binding domain of FG adsorbed to different materials so that evaluated the blood compatibility of those polymer biomaterials. |
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| Keywords: | monoclonal antibody FG adsorption binding affinity |
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