烷基双（1,1—二甲基—2—炔丙基）胺和1,8—丙炔萘的合成

研究烷基双（１，１－二甲基－２－炔丙基）胺和１，８－二乙炔萘的制备方法。方法 从廉价原料丙酮和乙炔出发，经６步反应制备未见献报道和烷基二炔丙胺８ａ，８ｂ，８ｃ和以萘甲酸酐为起始物经８步反应制备１，８－二丙炔萘。结果 合成未见献报道的烷基二炔丙胺，并对１，８－二丙炔萘的合成方法作了改进。结论 该方法可用于一些天然化合物的合成以及含炔丙胺的药物，材料的合成。

Preparation of Alkyl Bis(1,1 Dimethyl 2 Propargyl)amines and 1,8 Dipropynylnaphthalene

Aim To study the preparation of alkyl bis(1,1 dimethyl 2 propargyl) amines and 1,8 dipropynylnaphthalene. Methods Highly branched diacetylenic amines were prepared by coupling propargylamine with propargyl chloride, methylation on amine and terminally alkyl substitution. a convenient synthesis of 1,8 propynylnaphalene in 8 steps starting from naphthalic anhydride via Wittig reaction were also made. Results Preparation of alkyl bis(1,1 dimethyl 2 propargyl) amines was established, and preparation of 1,8 propynylnaphalene was improved. Conclusion These methods are available to the syntheses of natural products, drugs and synthetic materials containing propargyl amine.